Wormlike micellar aggregates of saponins from Ilex paraguariensis A. St. Hil. (mate): A characterisation by cryo-TEM, rheology, light scattering and small-angle neutron scattering

G. Peixoto, Maria Paula G., Treter, Janine, de Resende, Pedro Ernesto ORCID: https://orcid.org/0000-0001-7574-7975, da Silveira, Nádya Pesce, Ortega, George G., Lawrence, M. Jayne and Dreiss, Cécile A. (2011) Wormlike micellar aggregates of saponins from Ilex paraguariensis A. St. Hil. (mate): A characterisation by cryo-TEM, rheology, light scattering and small-angle neutron scattering. Journal of Pharmaceutical Sciences, 100 (2). pp. 536-546. ISSN 0022-3549

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Abstract

This work reports the physico-chemical characterisation of the micellar structures formed by a saponin fraction obtained from an important South American species, Ilex paraguariensis (mate). The mate saponin-enriched fraction (MSF) mainly comprises triterpenic glycosides and was obtained from mate green fruits through solid-phase extraction. The physico-chemical studies focused on the determination of the critical micellar concentration (CMC), the size and shape of the micelles, using conventional transmission electronic microscopy (TEM), as well as Cryo-TEM, light scattering and small-angle neutron scattering. The rheological behaviour of the solutions up to 4 wt% was also determined using a controlled-strain rheometer. Finally, the MSF ability to solubilise poorly water-soluble drugs was assayed using carbamazepine and flurbiprofen as basic and weak acidic drug models. Small spherical micelles of around 20 Å radius were observed in the presence of elongated structures with lengths of more than 500 nm, possessing a well-defined CMC of 0.41 g/L. MSF solutions ranging from 0.25 to 4% (w/v) demonstrated a viscoelastic behaviour independent of the concentration. MSF could improve the solubility of carbamazepine in the range of 0.13 to 1.5% (w/v)

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 18 Mar 2022 14:30
Last Modified: 22 Oct 2022 17:37
URI: https://ueaeprints.uea.ac.uk/id/eprint/84120
DOI: 10.1002/jps.22283

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