Wormlike micellar aggregates of saponins from Ilex paraguariensis A. St. Hil. (mate): A characterisation by cryo-TEM, rheology, light scattering and small-angle neutron scattering

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G. Peixoto, Maria Paula G., Treter, Janine, de Resende, Pedro Ernesto, da Silveira, Nádya Pesce, Ortega, George G., Lawrence, M. Jayne and Dreiss, Cécile A. (2011) Wormlike micellar aggregates of saponins from Ilex paraguariensis A. St. Hil. (mate): A characterisation by cryo-TEM, rheology, light scattering and small-angle neutron scattering. Journal of Pharmaceutical Sciences, 100 (2). pp. 536-546. ISSN 0022-3549

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Abstract

This work reports the physico-chemical characterisation of the micellar structures formed by a saponin fraction obtained from an important South American species, Ilex paraguariensis (mate). The mate saponin-enriched fraction (MSF) mainly comprises triterpenic glycosides and was obtained from mate green fruits through solid-phase extraction. The physico-chemical studies focused on the determination of the critical micellar concentration (CMC), the size and shape of the micelles, using conventional transmission electronic microscopy (TEM), as well as Cryo-TEM, light scattering and small-angle neutron scattering. The rheological behaviour of the solutions up to 4 wt% was also determined using a controlled-strain rheometer. Finally, the MSF ability to solubilise poorly water-soluble drugs was assayed using carbamazepine and flurbiprofen as basic and weak acidic drug models. Small spherical micelles of around 20 Å radius were observed in the presence of elongated structures with lengths of more than 500 nm, possessing a well-defined CMC of 0.41 g/L. MSF solutions ranging from 0.25 to 4% (w/v) demonstrated a viscoelastic behaviour independent of the concentration. MSF could improve the solubility of carbamazepine in the range of 0.13 to 1.5% (w/v)

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	18 Mar 2022 14:30
Last Modified:	21 Apr 2023 01:28
URI:	https://ueaeprints.uea.ac.uk/id/eprint/84120
DOI:	10.1002/jps.22283

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