Tools
Tools
Mastbergen, S. C., Ooms, A., Turmezei, T. D., MacKay, J. W. 
ORCID: https://orcid.org/0000-0001-7558-3800, van Heerwaarden, R. J., Spruijt, S., Lafeber, F. P. J. G. and Jansen, M. P.
(2022)
Subchondral bone changes after joint distraction treatment for end stage knee osteoarthritis.
Osteoarthritis and Cartilage, 30 (7).
pp. 965-972.
ISSN 1063-4584
Preview |
PDF (1-s2.0-S1063458422000322-main)
- Accepted Version
Available under License Creative Commons Attribution. Download (29MB) | Preview |
Abstract
Objective: Increased subchondral cortical bone plate thickness and trabecular bone density are characteristic of knee osteoarthritis (OA). Knee joint distraction (KJD) is a joint-preserving knee OA treatment where the joint is temporarily unloaded. It has previously shown clinical improvement and cartilage regeneration, indicating reversal of OA-related changes. The purpose of this research was to explore 3D subchondral bone changes after KJD treatment using CT imaging. Design: Twenty patients were treated with KJD and included to undergo knee CT imaging before, one, and two years after treatment. Tibia and femur segmentation and registration to canonical surfaces were performed semi-automatically. Cortical bone thickness and trabecular bone density were determined using an automated algorithm. Statistical parametric mapping (SPM) with two-tailed F-tests was used to analyze whole-joint changes. Results: Data was available of 16 patients. Subchondral cortical bone plate thickness and trabecular bone density were higher in the weight-bearing region of the most affected compartment (MAC; mostly medial). Especially the MAC showed a decrease in thickness and density in the first year after treatment, which was sustained towards the second year. Conclusions: KJD treatment results in bone changes that include thinning of the subchondral cortical bone plate and decrease of subchondral trabecular bone density in the first two years after treatment, potentially indicating a partial normalization of subchondral bone.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: The institution of MJ, SM and FL received grants from ZonMW (Project Number 95110008) during the conduct of the study. JM reports grants and personal fees from GlaxoSmithKline, personal fees from Moximed, and grants and personal fees from GE Healthcare, outside the submitted work; RH reports consulting fees from Newclip Technics, outside the submitted work; SS reports consulting fees from Zimmer Biomet Inc, outside the submitted work; FL reports consulting fees from SynerkinePharma BV, outside the submitted work. |
| Uncontrolled Keywords: | computed tomography,cortical,knee joint distraction,osteoarthritis,subchondral bone,trabecular,rheumatology,biomedical engineering,orthopedics and sports medicine ,/dk/atira/pure/subjectarea/asjc/2700/2745 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 15 Feb 2022 13:30 |
| Last Modified: | 22 Oct 2022 17:34 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/83498 |
| DOI: | 10.1016/j.joca.2021.12.014 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |