Evidence to underpin vitamin A requirements and upper limits in children aged 0 to 48 months: a scoping review

Hooper, Lee ORCID: https://orcid.org/0000-0002-7904-3331, Esio-Bassey, Chizoba, Brainard, Julii, Fynn, Judith, Jennings, Amy, Jones, Natalia ORCID: https://orcid.org/0000-0003-4025-2985, Tailor, Bhavesh V. ORCID: https://orcid.org/0000-0001-7534-5183, Abdelhamid, Asmaa, Coe, Calvin, Esgunoglu, Latife ORCID: https://orcid.org/0000-0002-8779-870X, Fallon, Ciara, Gyamfi, Ernestina, Hill, Claire, Howard Wilsher, Stephanie ORCID: https://orcid.org/0000-0002-3060-3270, Narayanan, Nithin, Oladosu, Titilopemi ORCID: https://orcid.org/0000-0001-8492-0960, Parkinson, Ellice ORCID: https://orcid.org/0000-0002-0226-4099, Prentice, Emma, Qurashi, Meysoon, Read, Luke, Getley, Harriet, Song, Fujian, Welch, Ailsa A., Aggett, Peter and Lietz, Georg (2022) Evidence to underpin vitamin A requirements and upper limits in children aged 0 to 48 months: a scoping review. Nutrients, 14 (3). ISSN 2072-6643

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Abstract

Vitamin A deficiency is a major health risk for infants and children in low-and middle-income countries. This scoping review identified, quantified, and mapped research for use in updating nutrient requirements and upper limits for vitamin A in children aged 0 to 48 months, using health-based or modelling-based approaches. Structured searches were run on Medline, EMBASE, and Cochrane Central, from inception to 19 March 2021. Titles and abstracts were assessed independently in duplicate, as were 20% of full texts. Included studies were tabulated by question, methodology and date, with the most relevant data extracted and assessed for risk of bias. We found that the most recent health-based systematic reviews and trials assessed the effects of supplementation, though some addressed the effects of staple food fortification, complementary foods, biofortified maize or cassava, and fortified drinks, on health outcomes. Recent isotopic tracer studies and modelling approaches may help quantify the effects of bio-fortification, fortification, and food-based approaches for increasing vitamin A depots. A systematic review and several trials identified adverse events associated with higher vitamin A intakes, which should be useful for setting upper limits. We have generated and provide a database of relevant research. Full systematic reviews, based on this scoping review, are needed to answer specific questions to set vitamin A requirements and upper limits.

Item Type: Article
Additional Information: Funding: This scoping review was funded by the World Health Organization, grant number 2021/1102552-0.
Uncontrolled Keywords: scoping review,vitamin a,infant,child,carotenoids,upper limits,recommended dietary allowances,nutritional requirements,retinol,world health organization,upper limits,nutritional requirements,recommended dietary allowances,retinol,scoping review,food science,nutrition and dietetics,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1100/1106
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Environmental Sciences
Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care
Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Faculty of Medicine and Health Sciences > Research Groups > UEA Hydrate Group
Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
University of East Anglia Schools > Faculty of Science > Tyndall Centre for Climate Change Research
Faculty of Science > Research Centres > Tyndall Centre for Climate Change Research
Faculty of Medicine and Health Sciences > Research Groups > Health Promotion
Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
Faculty of Medicine and Health Sciences > Research Centres > Institute for Volunteering Research
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Faculty of Medicine and Health Sciences > Research Centres > Population Health
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 10 Jan 2022 15:30
Last Modified: 25 Sep 2024 16:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/82949
DOI: 10.3390/nu14030407

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