Tools
Tools
Chew, Pei G., Dobson, Laura E., Garg, Pankaj 
ORCID: https://orcid.org/0000-0002-5483-169X, Fairbairn, Timothy A., Musa, Tarique A., Uddin, Akhlaque, Swoboda, Peter P., Foley, James R., Fent, Graham J., Brown, Louise A. E., Onciul, Sebastian, Plein, Sven, Blackman, Daniel J. and Greenwood, John P.
(2019)
CMR quantitation of change in mitral regurgitation following transcatheter aortic valve replacement (TAVR): impact on left ventricular reverse remodeling and outcome.
International Journal of Cardiovascular Imaging, 35.
pp. 161-170.
ISSN 1569-5794
Preview |
PDF (Published_Version)
- Published Version
Available under License Creative Commons Attribution. Download (1MB) | Preview |
Abstract
Current echocardiographic data reporting the impact of concomitant mitral regurgitation (MR) on outcome in patients who undergo transcatheter aortic valve replacement (TAVR) are conflicting. Using cardiovascular magnetic resonance (CMR) imaging, this study aimed to assess the impact of MR severity on cardiac reverse remodeling and patient outcome. 85 patients undergoing TAVR with CMR pre- and 6 m post-TAVR were evaluated. The CMR protocol included cines for left (LV) and right ventricular (RV) volumes, flow assessment, and myocardial scar assessment by late gadolinium enhancement (LGE). Patients were dichotomised according to CMR severity of MR fraction at baseline (‘non-significant’ vs ‘significant’) and followed up for a median duration of 3 years. Forty-two (49%) patients had ‘significant MR’ at baseline; they had similar LV and RV size and function compared to the ‘non-significant MR’ group but had greater LV mass at baseline. In those with significant MR at baseline, 77% (n = 32) had a reduction in MR post-TAVR, moving them into the ‘non-significant’ category at 6-months, with an overall reduction in MR fraction from 34 to 17% (p < 0.001). Improvement in MR was not associated with more favourable cardiac reverse remodeling when compared with the ‘non-improvers’. Significant MR at baseline was not associated with increased mortality at follow-up. Significant MR is common in patients undergoing TAVR and improves in the majority post-procedure. Improvement in MR was not associated with more favourable LV reverse remodeling and baseline MR severity was not associated with mortality.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Depositing User: | LivePure Connector |
| Date Deposited: | 20 Nov 2021 01:40 |
| Last Modified: | 19 Oct 2023 03:10 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/82251 |
| DOI: | 10.1007/s10554-018-1441-y |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |