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Swift, Andrew J., Wilson, Frederick, Cogliano, Marcella, Kendall, Lindsay, Alandejani, Faisal, Alabed, Samer, Hughes, Paul, Shahin, Yousef, Saunders, Laura, Oram, Charlotte, Capener, David, Rothman, Alex, Garg, Pankaj 
ORCID: https://orcid.org/0000-0002-5483-169X, Johns, Christopher, Austin, Matthew, Macdonald, Alistair, Pickworth, Jo, Hickey, Peter, Condliffe, Robin, Cahn, Anthony, Lawrie, Allan, Wild, Jim M and Kiely, David G
(2021)
Repeatability and sensitivity to change of non-invasive end points in PAH: the RESPIRE study.
Thorax, 76 (10).
pp. 1032-1035.
ISSN 0040-6376
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Abstract
End points that are repeatable and sensitive to change are important in pulmonary arterial hypertension (PAH) for clinical practice and trials of new therapies. In 42 patients with PAH, test-retest repeatability was assessed using the intraclass correlation coefficient and treatment effect size using Cohen's d statistic. Intraclass correlation coefficients demonstrated excellent repeatability for MRI, 6 min walk test and log to base 10 N-terminal pro-brain natriuretic peptide (log 10 NT-proBNP). The treatment effect size for MRI-derived right ventricular ejection fraction was large (Cohen's d 0.81), whereas the effect size for the 6 min walk test (Cohen's d 0.22) and log 10 NT-proBNP (Cohen's d 0.20) were fair. This study supports further evaluation of MRI as a non-invasive end point for clinical assessment and PAH therapy trials. Trial registration number NCT03841344.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This study was funded by GlaxoSmithKline (contract number COL100041816) and Wellcome Trust (205188/Z/16/Z and 206632/Z/17/Z). PH is funded by a research grant from GlaxoSmithKline (BIDS3000032592). |
| Uncontrolled Keywords: | ct mri etc,primary pulmonary hypertension,pulmonary and respiratory medicine ,/dk/atira/pure/subjectarea/asjc/2700/2740 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 13 Nov 2021 01:52 |
| Last Modified: | 25 Sep 2024 15:58 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/82093 |
| DOI: | 10.1136/thoraxjnl-2020-216078 |
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