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Tsampasian, Vasiliki, Swift, Andrew J., Assadi, Hosamadin 
ORCID: https://orcid.org/0000-0002-6143-8095, Chowdhary, Amrit, Swoboda, Peter, Sammut, Eva, Dastidar, Amardeep, Cabrero, Jordi Broncano, Del Val, Javier Royuela, Nair, Sunil, Nijveldt, Robin, Ryding, Alisdair, Sawh, Chris, Bucciarelli-Ducci, Chiara, Levelt, Eylem, Vassiliou, Vassilios ORCID: https://orcid.org/0000-0002-4005-7752 and Garg, Pankaj ORCID: https://orcid.org/0000-0002-5483-169X
(2021)
Myocardial inflammation and energetics by cardiac MRI: a review of emerging techniques.
BMC Medical Imaging, 21 (1).
ISSN 1471-2342
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Abstract
The role of inflammation in cardiovascular pathophysiology has gained a lot of research interest in recent years. Cardiovascular Magnetic Resonance has been a powerful tool in the non-invasive assessment of inflammation in several conditions. More recently, Ultrasmall superparamagnetic particles of iron oxide have been successfully used to evaluate macrophage activity and subsequently inflammation on a cellular level. Current evidence from research studies provides encouraging data and confirms that this evolving method can potentially have a huge impact on clinical practice as it can be used in the diagnosis and management of very common conditions such as coronary artery disease, ischaemic and non-ischaemic cardiomyopathy, myocarditis and atherosclerosis. Another important emerging concept is that of myocardial energetics. With the use of phosphorus magnetic resonance spectroscopy, myocardial energetic compromise has been proved to be an important feature in the pathophysiological process of several conditions including diabetic cardiomyopathy, inherited cardiomyopathies, valvular heart disease and cardiac transplant rejection. This unique tool is therefore being utilized to assess metabolic alterations in a wide range of cardiovascular diseases. This review systematically examines these state-of-the-art methods in detail and provides an insight into the mechanisms of action and the clinical implications of their use.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This work was funded in part by the Wellcome Trust [215799/Z/19/Z], [220703/Z/20/Z] and [205188/Z/16/Z]. The funding body played no role in the design of the study and collection, analysis, and interpretation of data and in writing the manuscript. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. |
| Uncontrolled Keywords: | cardiovascular magnetic resonance (cmr),magnetic resonance spectroscopy (mrs),ultrasmall superparamagnetic particles of iron oxide (uspio),radiology nuclear medicine and imaging,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2741 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 12 Nov 2021 02:04 |
| Last Modified: | 19 Oct 2023 03:08 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/82064 |
| DOI: | 10.1186/s12880-021-00695-0 |
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