Precious metal complexes of bis(pyridyl)allenes: Synthesis, catalytic and medicinal applications

Maliszewska, Hanna K., Arnau del Valle, Carla, Xia, Ying, Marín, María J. ORCID: https://orcid.org/0000-0001-8021-5498, Waller, Zoë A. E. and Muñoz, María Paz ORCID: https://orcid.org/0000-0001-9037-349X (2021) Precious metal complexes of bis(pyridyl)allenes: Synthesis, catalytic and medicinal applications. Dalton Transactions, 50 (45). pp. 16739-16750. ISSN 1477-9226

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Abstract

The incorporation of donor-type substituents on the allene core opens up the possibility of coordination complexes in which the metal is bonded to the donor groups, with or without interaction with the double bond system. Despite the challenges in the synthesis of such allene-containing metal complexes, their unique 3D environments and dual functionality (allene and metal) could facilitate catalysis and interaction with chemical and biological systems. Bis(pyridyl)allenes are presented here as robust ligands for novel Pd(II), Pt(IV) and Au(III) complexes. Their synthesis, characterisation and first application as catalysts of benchmark reactions for Pd, Pt and Au are presented with interesting reactivity and selectivities. The complexes have also been probed as antimicrobial and anticancer agents with promising activities, and the first studies on their unusual interaction with several DNA structures will open new avenues for research in the area of metallodrugs with new mechanisms of action.

Item Type: Article
Uncontrolled Keywords: inorganic chemistry ,/dk/atira/pure/subjectarea/asjc/1600/1604
Faculty \ School: Faculty of Science > School of Chemistry
Faculty of Science > School of Pharmacy
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Depositing User: LivePure Connector
Date Deposited: 05 Nov 2021 01:46
Last Modified: 22 Oct 2022 15:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/81980
DOI: 10.1039/D1DT02929K

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