Going round in circles – the Papez Circuit in Alzheimer’s Disease

Forno, Gonzalo, Lladó, Albert and Hornberger, Michael (2021) Going round in circles – the Papez Circuit in Alzheimer’s Disease. European Journal of Neuroscience, 54 (10). pp. 7668-7687. ISSN 0953-816X

[img] PDF (Accepted_Manuscript) - Accepted Version
Restricted to Repository staff only until 16 October 2022.

Download (1MB) | Request a copy


The hippocampus is regarded as the pivotal structure for episodic memory symptoms associated with Alzheimer's disease (AD) pathophysiology. However, what is often overlooked is that the hippocampus is ‘only’ one part of a network of memory critical regions, the Papez circuit. Other Papez circuit regions are often regarded as less relevant for AD as they are thought to sit ‘downstream’ of the hippocampus. However, this notion is oversimplistic, and increasing evidence suggests that other Papez regions might be affected before or concurrently with the hippocampus. In addition, AD research has mostly focused on episodic memory deficits, whereas spatial navigation processes are also subserved by the Papez circuit with increasing evidence supporting its valuable potential as a diagnostic measure of incipient AD pathophysiology. In the current review, we take a step forward analysing recent evidence on the structural and functional integrity of the Papez circuit across AD disease stages. Specifically, we will review the integrity of specific Papez regions from at-genetic-risk (APOE4 carriers), to mild cognitive impairment (MCI), to dementia stage of sporadic AD and autosomal dominant AD (ADAD). We related those changes to episodic memory and spatial navigation/orientation deficits in AD. Finally, we provide an overview of how the Papez circuit is affected in AD diseases and their specific symptomology contributions. This overview strengthened the need for moving away from a hippocampal-centric view to a network approach on how the whole Papez circuit is affected in AD and contributes to its symptomology, informing future research and clinical approaches.

Item Type: Article
Uncontrolled Keywords: anterior thalamic nucleus,episodic memory,hippocampus,posterior cingulate cortex,spatial navigation,neuroscience(all) ,/dk/atira/pure/subjectarea/asjc/2800
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 22 Oct 2021 01:44
Last Modified: 23 Nov 2021 01:39
URI: https://ueaeprints.uea.ac.uk/id/eprint/81859
DOI: 10.1111/ejn.15494

Actions (login required)

View Item View Item