Bis(N-picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus

Ghandhi, Laura H. D., Bidula, Stefan, Pask, Christopher M., Lord, Rianne M. and McGowan, Patrick C. (2021) Bis(N-picolinamido)cobalt(II) Complexes Display Antifungal Activity toward Candida albicans and Aspergillus fumigatus. ChemMedChem. ISSN 1860-7179

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Abstract

This report highlights the synthesis and characterization of ten new bis(N-picolinamido)cobalt(II) complexes of the type [(L) 2CoX 2] 0/2+, whereby L=N-picolinamide ligand and X=diisothiocyanato (−NCS), dichlorido (−Cl) or diaqua (−OH 2) ligands. Single crystal X-ray (SC-XRD) analysis for nine of the structures are reported and confirm the picolinamide ligand is bound to the Co(II) center through a neutral N,O binding mode. With the addition of powder X-ray diffraction (PXRD), we have confirmed the cis and trans ligand arrangements of each complex. All complexes were screened against several fungal species and show increased antifungal activity. Notably, these complexes had significant activity against strains of Candida albicans and Aspergillus fumigatus, with several compounds exhibiting growth inhibition of >80 %, and onecompound inhibiting Aspergillus fumigatus hyphal growth by >90 %. Conversely, no antifungal activity was exhibited toward Cryptococcus neoformans and no cytotoxicity towards mammalian cell lines.

Item Type: Article
Uncontrolled Keywords: aspergillus fumigatus,bioinorganic chemistry,candida albicans,cobalt complexes,picolinamide ligands,biochemistry,molecular medicine,pharmacology,drug discovery,pharmacology, toxicology and pharmaceutics(all),organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School: Faculty of Science > School of Biological Sciences
Faculty of Science > School of Chemistry
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Depositing User: LivePure Connector
Date Deposited: 05 Aug 2021 00:07
Last Modified: 16 Sep 2021 11:13
URI: https://ueaeprints.uea.ac.uk/id/eprint/80980
DOI: 10.1002/cmdc.202100159

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