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Ghandhi, Laura H. D., Bidula, Stefan 
ORCID: https://orcid.org/0000-0002-3790-7138, Pask, Christopher M., Lord, Rianne M. ORCID: https://orcid.org/0000-0001-9981-129X and McGowan, Patrick C.
(2021)
Bis(N-picolinamido)cobalt(II) complexes display antifungal activity toward Candida albicans and Aspergillus fumigatus.
ChemMedChem, 16 (20).
pp. 3210-3221.
ISSN 1860-7179
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Abstract
This report highlights the synthesis and characterization of ten new bis(N-picolinamido)cobalt(II) complexes of the type [(L) 2CoX 2] 0/2+, whereby L=N-picolinamide ligand and X=diisothiocyanato (−NCS), dichlorido (−Cl) or diaqua (−OH 2) ligands. Single crystal X-ray (SC-XRD) analysis for nine of the structures are reported and confirm the picolinamide ligand is bound to the Co(II) center through a neutral N,O binding mode. With the addition of powder X-ray diffraction (PXRD), we have confirmed the cis and trans ligand arrangements of each complex. All complexes were screened against several fungal species and show increased antifungal activity. Notably, these complexes had significant activity against strains of Candida albicans and Aspergillus fumigatus, with several compounds exhibiting growth inhibition of >80 %, and onecompound inhibiting Aspergillus fumigatus hyphal growth by >90 %. Conversely, no antifungal activity was exhibited toward Cryptococcus neoformans and no cytotoxicity towards mammalian cell lines.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | aspergillus fumigatus,bioinorganic chemistry,candida albicans,cobalt complexes,picolinamide ligands,biochemistry,molecular medicine,pharmacology,drug discovery,pharmacology, toxicology and pharmaceutics(all),organic chemistry ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences Faculty of Science > School of Chemistry (former - to 2024) |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Pathogen Biology Group |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 05 Aug 2021 00:07 |
| Last Modified: | 04 Nov 2024 00:49 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/80980 |
| DOI: | 10.1002/cmdc.202100159 |
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