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Paddock, Sophie, Tsampasian, Vasiliki, Assadi, Hosamadin 
ORCID: https://orcid.org/0000-0002-6143-8095, Mota, Bruno Calife, Swift, Andrew J., Chowdhary, Amrit, Swoboda, Peter, Levelt, Eylem, Sammut, Eva, Dastidar, Amardeep, Broncano Cabrero, Jordi, Del Val, Javier Royuela, Malcolm, Paul, Sun, Julia, Ryding, Alisdair, Sawh, Chris, Greenwood, Richard, Hewson, David, Vassiliou, Vassilios ORCID: https://orcid.org/0000-0002-4005-7752 and Garg, Pankaj ORCID: https://orcid.org/0000-0002-5483-169X
(2021)
Clinical translation of three-dimensional scar, diffusion tensor imaging, four-dimensional flow, and quantitative perfusion in cardiac MRI: A comprehensive review.
Frontiers in Cardiovascular Medicine, 8.
ISSN 2297-055X
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Abstract
Cardiovascular magnetic resonance (CMR) imaging is a versatile tool that has established itself as the reference method for functional assessment and tissue characterisation. CMR helps to diagnose, monitor disease course and sub-phenotype disease states. Several emerging CMR methods have the potential to offer a personalised medicine approach to treatment. CMR tissue characterisation is used to assess myocardial oedema, inflammation or thrombus in various disease conditions. CMR derived scar maps have the potential to inform ablation therapy—both in atrial and ventricular arrhythmias. Quantitative CMR is pushing boundaries with motion corrections in tissue characterisation and first-pass perfusion. Advanced tissue characterisation by imaging the myocardial fibre orientation using diffusion tensor imaging (DTI), has also demonstrated novel insights in patients with cardiomyopathies. Enhanced flow assessment using four-dimensional flow (4D flow) CMR, where time is the fourth dimension, allows quantification of transvalvular flow to a high degree of accuracy for all four-valves within the same cardiac cycle. This review discusses these emerging methods and others in detail and gives the reader a foresight of how CMR will evolve into a powerful clinical tool in offering a precision medicine approach to treatment, diagnosis, and detection of disease.
| Item Type: | Article |
|---|---|
| Additional Information: | Funding Information: This work was funded in part by the Wellcome Trust [215799/Z/19/Z] and [205188/Z/16/Z]. For the purpose of Open Access, the author has applied a CC BY public copyright licence to any Author Accepted Manuscript version arising from this submission. |
| Uncontrolled Keywords: | cardiovascular magnetic resonance,diffusion tensor imaging,four-dimensional flow imaging,myocardial fibrosis,tissue characterisation,cardiology and cardiovascular medicine ,/dk/atira/pure/subjectarea/asjc/2700/2705 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 29 Jul 2021 00:11 |
| Last Modified: | 19 Oct 2023 03:03 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/80878 |
| DOI: | 10.3389/fcvm.2021.682027 |
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