Reducing the global burden of depression: Population-level analysis of intervention cost-effectiveness in 14 world regions

Chisholm, Dan, Sanderson, Kristy, Ayuso-Mateos, Jose Luis and Saxena, Shekhar (2004) Reducing the global burden of depression: Population-level analysis of intervention cost-effectiveness in 14 world regions. British Journal of Psychiatry, 184 (5). pp. 393-403. ISSN 1472-1465

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Abstract

Background: International evidence on the cost and effects of interventions for reducing the global burden of depression remain scarce. Aims: To estimate the population-level cost-effectiveness of evidence-based depression interventions and their contribution towards reducing current burden. Method: Primary-care-based depression interventions were modelled at the level of whole populations in 14 epidemiological subregions of the world. Total population-level costs (in international dollars or I) and effectiveness (disability adjusted life years (DALYs) averted) were combined to form average and incremental cost-effectiveness ratios. Results: Evaluated interventions have the potential to reduce the current burden of depression by 10–30%. Pharmacotherapy with older antidepressant drugs, with or without proactive collaborative care, are currently more cost-effective strategies than those using newer antidepressants, particularly in lower-income subregions. Conclusions: Even in resource-poor regions, each DALYaverted by efficient depression treatments in primary care costs less than 1 year of average per capita income, making such interventions a cost-effective use of health resources. However, current levels of burden can only be reduced significantly if there is a substantial increase in treatment coverage.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Depositing User: LivePure Connector
Date Deposited: 16 Jul 2021 00:18
Last Modified: 21 Jul 2021 01:50
URI: https://ueaeprints.uea.ac.uk/id/eprint/80608
DOI: 10.1192/bjp.184.5.393

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