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Chisholm, Dan, Sanderson, Kristy 
ORCID: https://orcid.org/0000-0002-3132-2745, Ayuso-Mateos, Jose Luis and Saxena, Shekhar
(2004)
Reducing the global burden of depression: Population-level analysis of intervention cost-effectiveness in 14 world regions.
British Journal of Psychiatry, 184 (5).
pp. 393-403.
ISSN 1472-1465
Abstract
Background: International evidence on the cost and effects of interventions for reducing the global burden of depression remain scarce. Aims: To estimate the population-level cost-effectiveness of evidence-based depression interventions and their contribution towards reducing current burden. Method: Primary-care-based depression interventions were modelled at the level of whole populations in 14 epidemiological subregions of the world. Total population-level costs (in international dollars or I) and effectiveness (disability adjusted life years (DALYs) averted) were combined to form average and incremental cost-effectiveness ratios. Results: Evaluated interventions have the potential to reduce the current burden of depression by 10–30%. Pharmacotherapy with older antidepressant drugs, with or without proactive collaborative care, are currently more cost-effective strategies than those using newer antidepressants, particularly in lower-income subregions. Conclusions: Even in resource-poor regions, each DALYaverted by efficient depression treatments in primary care costs less than 1 year of average per capita income, making such interventions a cost-effective use of health resources. However, current levels of burden can only be reduced significantly if there is a substantial increase in treatment coverage.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Depositing User: | LivePure Connector |
| Date Deposited: | 16 Jul 2021 00:18 |
| Last Modified: | 19 Oct 2023 03:02 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/80608 |
| DOI: | 10.1192/bjp.184.5.393 |
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