Activities of daily living in behavioral variant frontotemporal dementia: Differences in caregiver and performance-based assessments

Mioshi, Eneida, Kipps, Christopher M. and Hodges, John R. (2009) Activities of daily living in behavioral variant frontotemporal dementia: Differences in caregiver and performance-based assessments. Alzheimer Disease and Associated Disorders, 23 (1). pp. 70-76. ISSN 0893-0341

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Abstract

Patients with the behavioral variant of frontotemporal dementia have marked impairment in everyday life, yet little is known about factors underlying this impairment. Moreover, a recently identified subgroup with normal brain imaging has an excellent prognosis (phenocopy cases) and their performance on activities of daily living (ADL) tasks is unknown. Eighteen behavioral variant frontotemporal dementia patients were assessed on 2 ADL measures, the Disability Assessment for Dementia, a caregiver-based interview, and the Assessment of Motor and Process Skills, a performance-based instrument. Behavior change, global cognition, executive function, and magnetic resonance imaging brain atrophy were also evaluated. There was no association between the 2 ADL measures. A model combining the Addenbrooke's Cognitive Examination Revised (global cognition) and Frontal Systems Behavior Scale (frontal dysfunction) explained the variance on ADL performance. A qualitative rating distinguished between pathologic and phenocopy patients better than the performance-based assessment. Degree of frontal dysfunction and overall dementia determined the level of ADL impairment. The phenocopy patients were clearly distinguishable when evaluated using a performance-based, and even better with a qualitative rating assessment.

Item Type:	Article
Uncontrolled Keywords:	activities of daily living,physiology,caregivers,physiology,pathology,female,humans,magnetic resonance imaging,male,middle aged,neuropsychological tests,severity of illness index
Depositing User:	LivePure Connector
Date Deposited:	09 Jul 2021 07:29
Last Modified:	23 Oct 2022 02:38
URI:	https://ueaeprints.uea.ac.uk/id/eprint/80494
DOI:	10.1097/wad.0b013e318182d293

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