Longitudinal changes in primary progressive aphasias: Differences in cognitive and dementia staging measures

Hsieh, S., Hodges, J. R., Leyton, C. E. and Mioshi, E. (2012) Longitudinal changes in primary progressive aphasias: Differences in cognitive and dementia staging measures. Dementia and Geriatric Cognitive Disorders, 34 (2). pp. 135-141. ISSN 1420-8008

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Abstract

BACKGROUND/AIMS: The longitudinal course of three primary progressive aphasia (PPA) variants was examined using Addenbrooke's Cognitive Examination-Revised (ACE-R) and the Frontotemporal dementia Rating Scale (FRS). METHODS: Cases with two assessments on the ACE-R and FRS were selected. A total of 220 assessments were obtained on 55 patients: 17 Alzheimer's disease (AD) and 38 PPA [17 semantic variant (svPPA), 12 non-fluent/agrammatic (naPPA) and 9 logopenic variant (lvPPA) cases]. RESULTS: The annualized rate of change was greater in all PPA variants in comparison with the AD group on the ACE-R whereas only the svPPA and naPPA groups differed from AD on the FRS. CONCLUSIONS: The longitudinal profile differs across PPA syndromes on cognitive and functional measures. Findings have theoretical implications and are relevant to the care of patients with dementia.

Item Type: Article
Uncontrolled Keywords: aged,diagnosis,diagnosis,disease progression,female,humans,longitudinal studies,male,middle aged,neuropsychological tests,diagnosis
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
Depositing User: LivePure Connector
Date Deposited: 09 Jul 2021 07:29
Last Modified: 30 Sep 2021 16:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/80484
DOI: 10.1159/000342347

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