Rodent models of Spondyloarthritis have decreased white and bone marrow adipose tissue depots

Furesi, Giulia, Fert, Ingrid, Beaufrère, Marie, Araujo, Luiza M., Glatigny, Simon, Baschant, Ulrike, von Bonin, Malte, Hofbauer, Lorenz C., Horwood, Nicole J. ORCID:, Breban, Maxime and Rauner, Martina (2021) Rodent models of Spondyloarthritis have decreased white and bone marrow adipose tissue depots. Frontiers in Immunology, 12. ISSN 1664-3224

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Bone marrow adipose tissue (BMAT) has recently been recognized as a distinct fat depot with endocrine functions. However, if and how it is regulated by chronic inflammation remains unknown. Here, we investigate the amount of white fat and BMAT in HLA-B27 transgenic rats and curdlan-challenged SKG mice, two well-established models of chronic inflammatory spondyloarthritis (SpA). Subcutaneous and gonadal white adipose tissue and BMAT was reduced by 65-70% and by up to 90% in both experimental models. Consistently, B27 rats had a 2-3-fold decrease in the serum concentrations of the adipocyte-derived cytokines adiponectin and leptin as well as a 2-fold lower concentration of triglycerides. The bone marrow of B27 rats was further characterized by higher numbers of neutrophils, lower numbers of erythroblast precursors, and higher numbers of IL-17 producing CD4+ T cells. IL-17 concentration was also increased in the serum of B27 rats. Using a cell culture model, we show that high levels of IL-17 in the serum of B27 rats negatively impacted adipogenesis (-76%), an effect that was reversed in the presence of neutralizing anti-IL-17 antibody. In summary, these findings show BMAT is severely reduced in two experimental models of chronic inflammatory SpA and suggest that IL-17 is involved in this process.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
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Depositing User: LivePure Connector
Date Deposited: 24 Jun 2021 00:12
Last Modified: 19 Oct 2023 02:59
DOI: 10.3389/fimmu.2021.665208


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