Tools
Tools
Furesi, Giulia, Fert, Ingrid, Beaufrère, Marie, Araujo, Luiza M., Glatigny, Simon, Baschant, Ulrike, von Bonin, Malte, Hofbauer, Lorenz C., Horwood, Nicole J. 
ORCID: https://orcid.org/0000-0002-6344-1677, Breban, Maxime and Rauner, Martina
(2021)
Rodent models of Spondyloarthritis have decreased white and bone marrow adipose tissue depots.
Frontiers in Immunology, 12.
ISSN 1664-3224
Preview |
PDF (Published_Version)
- Published Version
Available under License Creative Commons Attribution. Download (2MB) | Preview |
Abstract
Bone marrow adipose tissue (BMAT) has recently been recognized as a distinct fat depot with endocrine functions. However, if and how it is regulated by chronic inflammation remains unknown. Here, we investigate the amount of white fat and BMAT in HLA-B27 transgenic rats and curdlan-challenged SKG mice, two well-established models of chronic inflammatory spondyloarthritis (SpA). Subcutaneous and gonadal white adipose tissue and BMAT was reduced by 65-70% and by up to 90% in both experimental models. Consistently, B27 rats had a 2-3-fold decrease in the serum concentrations of the adipocyte-derived cytokines adiponectin and leptin as well as a 2-fold lower concentration of triglycerides. The bone marrow of B27 rats was further characterized by higher numbers of neutrophils, lower numbers of erythroblast precursors, and higher numbers of IL-17 producing CD4+ T cells. IL-17 concentration was also increased in the serum of B27 rats. Using a cell culture model, we show that high levels of IL-17 in the serum of B27 rats negatively impacted adipogenesis (-76%), an effect that was reversed in the presence of neutralizing anti-IL-17 antibody. In summary, these findings show BMAT is severely reduced in two experimental models of chronic inflammatory SpA and suggest that IL-17 is involved in this process.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 24 Jun 2021 00:12 |
| Last Modified: | 25 Oct 2024 23:55 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/80326 |
| DOI: | 10.3389/fimmu.2021.665208 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |