Unboxing mutations: Connecting mutation types with evolutionary consequences

Berdan, Emma L., Blanckaert, Alexandre, Slotte, Tanja, Suh, Alexander ORCID: https://orcid.org/0000-0002-8979-9992, Westram, Anja M. and Fragata, Inês (2021) Unboxing mutations: Connecting mutation types with evolutionary consequences. Molecular Ecology, 30 (12). pp. 2710-2723. ISSN 0962-1083

Preview

PDF (Published_Version) - Published Version Available under License Creative Commons Attribution Non-commercial. Download (1MB) | Preview

Abstract

A key step in understanding the genetic basis of different evolutionary outcomes (e.g., adaptation) is to determine the roles played by different mutation types (e.g., SNPs, translocations and inversions). To do this we must simultaneously consider different mutation types in an evolutionary framework. Here, we propose a research framework that directly utilizes the most important characteristics of mutations, their population genetic effects, to determine their relative evolutionary significance in a given scenario. We review known population genetic effects of different mutation types and show how these may be connected to different evolutionary outcomes. We provide examples of how to implement this framework and pinpoint areas where more data, theory and synthesis are needed. Linking experimental and theoretical approaches to examine different mutation types simultaneously is a critical step towards understanding their evolutionary significance.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Biological Sciences
Related URLs:	https://onlinelibrary.wiley.com/doi/10.1...
Depositing User:	LivePure Connector
Date Deposited:	28 May 2021 00:33
Last Modified:	05 Apr 2024 14:32
URI:	https://ueaeprints.uea.ac.uk/id/eprint/80143
DOI:	10.1111/mec.15936

Downloads

Actions (login required)

View Item