New perspectives on the evolution of within-individual genome variation and germline/soma distinction

Suh, Alexander and Dion-Côté, Anne-Marie (2021) New perspectives on the evolution of within-individual genome variation and germline/soma distinction. Genome Biology and Evolution, 13 (6). ISSN 1759-6653

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Genomes can vary significantly even within the same individual. The underlying mechanisms are manifold, ranging from somatic mutation and recombination, development-associated ploidy changes and genetic bottlenecks, over to programmed DNA elimination during germline/soma differentiation. In this perspective piece, we briefly review recent developments in the study of within-individual genome variation in eukaryotes and prokaryotes. We highlight a Society for Molecular Biology and Evolution 2020 virtual symposium entitled "Within-individual genome variation and germline/soma distinction" and the present Special Section of the same name in Genome Biology and Evolution, together fostering cross-taxon synergies in the field to identify and tackle key open questions in the understanding of within-individual genome variation.

Item Type: Article
Additional Information: Funding Information: A.S. was supported by the Swedish Research Council Vetenskapsrådet (2016-05139, 2020-04436) and the Swedish Research Council Formas (2017-01597). A.-M.D.-C. was supported by the National Sciences and Engineering Research Council of Canada (RGPIN-2019-05744).
Uncontrolled Keywords: dna elimination,chromatin diminution,germline-restricted chromosome,soma variation,ecology, evolution, behavior and systematics,genetics ,/dk/atira/pure/subjectarea/asjc/1100/1105
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 27 May 2021 00:10
Last Modified: 31 Mar 2022 09:30
DOI: 10.1093/gbe/evab095

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