Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans

Ivimey-Cook, Edward R., Sales, Kris, Carlsson, Hanne, Immler, Simone, Chapman, Tracey and Maklakov, Alexei A. (2021) Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans. Proceedings of the Royal Society B: Biological Sciences, 288 (1950). ISSN 0962-8452

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Abstract

Dietary restriction (DR) increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here, we investigated the effect of DR by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in Caenorhabditis elegans. We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P0), it has a wide range of both positive and negative effects on their descendants (F1–F3). Remarkably, great-grandparental exposure to TF in early life reduces fitness and increases mortality risk of F3 descendants to such an extent that TF no longer promotes a lifespan extension. These findings reveal that transgenerational trade-offs accompany the instant benefits of DR, underscoring the need to consider fitness of future generations in pursuit of healthy ageing.

Item Type: Article
Uncontrolled Keywords: ageing,dietary restriction,longevity,reproduction,senescence,immunology and microbiology(all),biochemistry, genetics and molecular biology(all),environmental science(all),agricultural and biological sciences(all) ,/dk/atira/pure/subjectarea/asjc/2400
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 27 May 2021 00:10
Last Modified: 16 Sep 2021 11:11
URI: https://ueaeprints.uea.ac.uk/id/eprint/80131
DOI: 10.1098/rspb.2021.0701

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