Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans

Ivimey-Cook, Edward R. ORCID: https://orcid.org/0000-0003-4910-0443, Sales, Kris ORCID: https://orcid.org/0000-0002-7568-2507, Carlsson, Hanne, Immler, Simone, Chapman, Tracey and Maklakov, Alexei A. ORCID: https://orcid.org/0000-0002-5809-1203 (2021) Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans. Proceedings of the Royal Society B: Biological Sciences, 288 (1950). ISSN 0962-8452

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Abstract

Dietary restriction (DR) increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here, we investigated the effect of DR by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in Caenorhabditis elegans. We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P0), it has a wide range of both positive and negative effects on their descendants (F1–F3). Remarkably, great-grandparental exposure to TF in early life reduces fitness and increases mortality risk of F3 descendants to such an extent that TF no longer promotes a lifespan extension. These findings reveal that transgenerational trade-offs accompany the instant benefits of DR, underscoring the need to consider fitness of future generations in pursuit of healthy ageing.

Item Type: Article
Uncontrolled Keywords: ageing,dietary restriction,longevity,reproduction,senescence,immunology and microbiology(all),biochemistry, genetics and molecular biology(all),environmental science(all),agricultural and biological sciences(all) ,/dk/atira/pure/subjectarea/asjc/2400
Faculty \ School: Faculty of Science > School of Biological Sciences
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Depositing User: LivePure Connector
Date Deposited: 27 May 2021 00:10
Last Modified: 22 Oct 2022 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/80131
DOI: 10.1098/rspb.2021.0701

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