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Ivimey-Cook, Edward R. 
ORCID: https://orcid.org/0000-0003-4910-0443, Sales, Kris, Carlsson, Hanne, Immler, Simone, Chapman, Tracey and Maklakov, Alexei A. ORCID: https://orcid.org/0000-0002-5809-1203
(2021)
Transgenerational fitness effects of lifespan extension by dietary restriction in Caenorhabditis elegans.
Proceedings of the Royal Society B: Biological Sciences, 288 (1950).
ISSN 0962-8452
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Abstract
Dietary restriction (DR) increases lifespan in a broad variety of organisms and improves health in humans. However, long-term transgenerational consequences of dietary interventions are poorly understood. Here, we investigated the effect of DR by temporary fasting (TF) on mortality risk, age-specific reproduction and fitness across three generations of descendants in Caenorhabditis elegans. We show that while TF robustly reduces mortality risk and improves late-life reproduction of the individuals subject to TF (P0), it has a wide range of both positive and negative effects on their descendants (F1–F3). Remarkably, great-grandparental exposure to TF in early life reduces fitness and increases mortality risk of F3 descendants to such an extent that TF no longer promotes a lifespan extension. These findings reveal that transgenerational trade-offs accompany the instant benefits of DR, underscoring the need to consider fitness of future generations in pursuit of healthy ageing.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ageing,dietary restriction,longevity,reproduction,senescence,immunology and microbiology(all),biochemistry, genetics and molecular biology(all),environmental science(all),agricultural and biological sciences(all) ,/dk/atira/pure/subjectarea/asjc/2400 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences |
| UEA Research Groups: | Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 27 May 2021 00:10 |
| Last Modified: | 17 Dec 2024 01:32 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/80131 |
| DOI: | 10.1098/rspb.2021.0701 |
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