Biomarkers associated with mortality in aortic stenosis: A systematic review and meta-analysis

White, Madeline, Baral, Ranu, Ryding, Alisdair, Tsampasian, Vasiliki, Ravindrarajah, Thuwarahan, Garg, Pankaj ORCID: https://orcid.org/0000-0002-5483-169X, Koskinas, Konstantinos C., Clark, Allan ORCID: https://orcid.org/0000-0003-2965-8941 and Vassiliou, Vassilios S. ORCID: https://orcid.org/0000-0002-4005-7752 (2021) Biomarkers associated with mortality in aortic stenosis: A systematic review and meta-analysis. Medical Sciences, 9 (2). ISSN 2076-3271

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Abstract

The optimal timing of aortic valve replacement (AVR) remains controversial. Several biomarkers reflect the underlying pathophysiological processes in aortic stenosis (AS) and may be of use as mortality predictors. The aim of this systematic review and meta-analysis is to evaluate the blood biomarkers utilised in AS and assess whether they associate with mortality. PubMed and Embase were searched for studies reporting baseline biomarker level and mortality outcomes in patients with AS. A total of 83 studies met the inclusion criteria and were systematically reviewed. Of these, 21 reporting brain natriuretic peptide (BNP), N-terminal pro B-type natriuretic peptide (NT-proBNP), Troponin and Galectin-3 were meta-analysed. Pooled analysis demonstrated that all-cause mortality was significantly associated with elevated baseline levels of BNP (HR 2.59; 95% CI 1.95–3.44; p < 0.00001), NT-proBNP (HR 1.73; 95% CI 1.45–2.06; p = 0.00001), Troponin (HR 1.65; 95% CI 1.31–2.07; p < 0.0001) and Galectin-3 (HR 1.82; 95% CI 1.27–2.61; p < 0.001) compared to lower baseline biomarker levels. Elevated levels of baseline BNP, NT-proBNP, Troponin and Galectin-3 were associated with increased all-cause mortality in a population of patients with AS. Therefore, a change in biomarker level could be considered to refine optimal timing of intervention. The results of this meta-analysis highlight the importance of biomarkers in risk stratification of AS, regardless of symptom status.

Item Type:	Article
Uncontrolled Keywords:	aortic valve stenosis,biomarkers,meta-analysis,mortality,medicine(all) ,/dk/atira/pure/subjectarea/asjc/2700
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Science > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre Faculty of Medicine and Health Sciences > Research Centres > Population Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health
Related URLs:	http://www.scopus.com/inward/record.url?... https://www.mdpi.com/2076-3271/9/2/29
Depositing User:	LivePure Connector
Date Deposited:	27 May 2021 00:09
Last Modified:	25 Sep 2024 15:36
URI:	https://ueaeprints.uea.ac.uk/id/eprint/80120
DOI:	10.3390/medsci9020029

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