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Mackay, James 
ORCID: https://orcid.org/0000-0001-7558-3800, Guermazi, Ali, Kwoh, C. Kent, See, P. L. Paul, Jarraya, Mohamed, Li, Ling, Hannon, Michael J., Fujii, Tomoko and Roemer, Frank W.
(2022)
Magnetic resonance imaging-defined osteophyte presence and concomitant cartilage damage in knees with incident tibiofemoral osteoarthritis: Data from the Pivotal Osteoarthritis Initiative Magnetic Resonance Imaging Analyses study.
Arthritis Care & Research, 74 (9).
pp. 1513-1519.
ISSN 2151-464X
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Abstract
Objective: To describe compartmental frequencies of magnetic resonance image (MRI)–defined osteophytes and co-localized cartilage damage and evaluate the associations of osteophyte size with any ipsicompartmental cartilage damage in knees with incident tibiofemoral radiographic knee osteoarthritis (OA). Methods: We evaluated knees from the Osteoarthritis Initiative without radiographic knee OA at baseline that developed radiographic knee OA during a 4-year interval. Semiquantitative MRI scoring of osteophytes and cartilage damage was performed at the time point when radiographic knee OA was diagnosed, defined as Kellgren/Lawrence grade of ≥2, using the MRI Osteoarthritis Knee Score instrument. The frequencies of maximum osteophyte size and maximum grade of ipsicompartmental (i.e., patellofemoral, medial tibiofemoral, lateral tibiofemoral, posterior femur) cartilage damage were assessed. Generalized estimating equations were used to determine the association of MRI-defined maximum osteophyte size with presence of any (excluding focal superficial defects) ipsicompartmental cartilage damage. Results: A total of 296 knees that did not have tibiofemoral radiographic knee OA at the baseline visit but developed radiographic knee OA during the 48-month observational period were included. In the patellofemoral, medial tibiofemoral, and lateral tibiofemoral compartments, the most frequent osteophyte grade was 1 (67.6%, 59.1%, and 51.7%, respectively) and was 0 (51.7%) in the posterior femur. For all compartments except the posterior femur, a linear trend was found between increasing maximum osteophyte size and the presence of any concomitant cartilage damage. Conclusion: In this sample of knees with incident tibiofemoral radiographic knee OA, the patellofemoral joint showed more severe cartilage damage than other compartments regardless of concomitant osteophyte size. In the posterior femur, cartilage damage was rare despite the presence or size of concomitant osteophytes.
| Item Type: | Article |
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| Additional Information: | Funding Information: The study and image acquisition was funded by the OAI, a public–private partnership between the NIH (contracts N01‐AR‐2‐2258, N01‐AR‐2‐2259, N01‐AR‐2‐2260, N01‐AR‐2‐2261, and N01‐AR‐2‐2262) and private funding partners (Merck Research Laboratories, Novartis Pharmaceuticals, GlaxoSmithKline, and Pfizer, Inc.) and is conducted by the OAI Study Investigators. Private sector funding for the OAI is managed by the Foundation for the NIH. The authors of this article are not part of the OAI investigative team. The image analysis of this study was funded in part by Novartis Pharma AG (Basel, Switzerland), in part by a contract with the University of Pittsburgh (Pivotal OAI Magnetic Resonance Imaging Analyses [POMA]: NIH/National Heart, Lung and Blood Institute [NHLBI] grant HHSN2682010000 21C) and in part by a vendor contract from the OAI coordinating center at University of California, San Francisco (grant N01‐AR‐2‐2258). The statistical data analysis was funded in part by a contract with the University of Pittsburgh (POMA: NIH/NHLBI grant HHSN2682010000 21C) and by the Biomarker of Early osteoArthritis of the Knee (BEAK) study (AR066601). |
| Uncontrolled Keywords: | rheumatology ,/dk/atira/pure/subjectarea/asjc/2700/2745 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 14 May 2021 00:06 |
| Last Modified: | 23 Oct 2022 02:27 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/80013 |
| DOI: | 10.1002/acr.24605 |
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