A Feasibility Randomised Controlled Trial of a Brief Early Intervention for Adolescent Depression that Targets Emotional Mental Images and Memory Specificity (IMAGINE trial)

Pile, Victoria, Smith, Patrick, Leamy, Mary, Oliver, Abigail, Bennett, Eleanor, Blackwell, Simon E., Meiser-Stedman, Richard, Stringer, Dominic, Dunn, Barnaby D., Holmes, Emily A. and Lau, Jennifer Y. F. (2021) A Feasibility Randomised Controlled Trial of a Brief Early Intervention for Adolescent Depression that Targets Emotional Mental Images and Memory Specificity (IMAGINE trial). Behaviour Research and Therapy. ISSN 0005-7967

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Abstract

Brief, evidence-based interventions for adolescent depression are urgently required, particularly for school-settings. Cognitive mechanisms research suggests dysfunctional mental imagery and overgeneral memory could be promising targets to improve mood. This feasibility randomised controlled trial with parallel symptomatic groups (n=56) compared a novel imagery-based cognitive behavioural intervention (ICBI) to non-directive supportive therapy (NDST) in school settings. Blind assessments (of clinical symptoms and cognitive mechanisms) took place pre-intervention, post-intervention and follow-up three months later. The trial aimed to evaluate the feasibility and acceptability of the methodology and interventions, and estimate the likely range of effects of the intervention on self-reported depression. The pre-defined criteria for proceeding to a definitive RCT were met: full recruitment occurred within eleven months; retention was 89%; ICBI acceptability was above satisfactory; and no harm was indicated. Intention-to-treat analysis found large effects in favour of ICBI (relative to NDST) at post-intervention in reducing depressive symptoms (d=-1.34, 95% CI [-1.87, -0.80]) and improving memory specificity (d=0.79 [0.35, 1.23]), a key cognitive target. The findings suggest that ICBI may not only improve mood but also strengthen abilities associated with imagining and planning the future, critical skills at this life stage. A fully powered evaluation of ICBI is warranted.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: LivePure Connector
Date Deposited: 28 Apr 2021 23:47
Last Modified: 02 May 2021 23:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/79893
DOI: 10.1016/j.brat.2021.103876

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