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Kassavou, Aikaterini, Mirzaei, Venus, Shpendi, Sonia, Brimicombe, James, Chauhan, Jagmohan, Bhattacharya, Debi 
ORCID: https://orcid.org/0000-0003-3024-7453, Naughton, Felix, Hardeman, Wendy ORCID: https://orcid.org/0000-0002-6498-9407, Eborall, Helen, van Emmenis, Miranda, De Simoni, Anna, Takhar, Amrit, Gupta, Pankaj, Patel, Prashanth, Mascolo, Cecilia, Prevost, Andrew Toby, Morris, Stephen, Griffin, Simon, McManus, Richard J., Mant, Jonathan and Sutton, Stephen
(2021)
The feasibility of the PAM intervention to support treatment-adherence in people with hypertension in primary care. A randomised clinical controlled trial.
Scientific Reports, 11.
ISSN 2045-2322
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Abstract
The PAM intervention is a behavioural intervention to support adherence to anti-hypertensive medications and therefore to lower blood pressure. This feasibility trial recruited 101 nonadherent patients (54% male, mean age 65.8 years) with hypertension and high blood pressure from nine general practices in the UK. The trial had 15.5% uptake and 7.9% attrition rate. Patients were randomly allocated to two groups: the intervention group (n = 61) received the PAM intervention as an adjunct to usual care; the control group (n = 40) received usual care only. At 3 months, biochemically validated medication adherence was improved by 20% (95% CI 3-36%) in the intervention than control, and systolic blood pressure was reduced by 9.16 mmHg (95% CI 5.69-12.64) in intervention than control. Improvements in medication adherence and reductions in blood pressure suggested potential intervention effectiveness. For a subsample of patients, improvements in medication adherence and reductions in full lipid profile (cholesterol 1.39 mmol/mol 95% CI 0.64-1.40) and in glycated haemoglobin (3.08 mmol/mol, 95% CI 0.42-5.73) favoured the intervention. A larger trial will obtain rigorous evidence about the potential clinical effectiveness and cost-effectiveness of the intervention.Trial registration Trial date of first registration 28/01/2019. ISRCTN74504989. https://doi.org/10.1186/ISRCTN74504989 .
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy Faculty of Medicine and Health Sciences > School of Health Sciences |
| UEA Research Groups: | Faculty of Science > Research Groups > Patient Care Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Medicine and Health Sciences > Research Groups > Behavioural and Implementation Science Faculty of Medicine and Health Sciences > Research Groups > Health Promotion Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 19 Apr 2021 23:50 |
| Last Modified: | 19 Oct 2023 02:57 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/79814 |
| DOI: | 10.1038/s41598-021-88170-2 |
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