Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial

Clark, Lucy ORCID: https://orcid.org/0000-0001-7162-0512, McCrone, Paul, Pesola, Francesca, Vergara-Williamson, Mario and White, Peter D. (2021) Guided graded exercise self-help for chronic fatigue syndrome: Long term follow up and cost-effectiveness following the GETSET trial. Journal of Psychosomatic Research, 146. ISSN 0022-3999

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Abstract

Objective: The GETSET trial found that guided graded exercise self-help (GES) improved fatigue and physical functioning more than specialist medical care (SMC) alone in adults with chronic fatigue syndrome (CFS) 12-weeks after randomisation. In this paper, we assess the longer-term clinical and health economic outcomes. Methods: GETSET was a randomised controlled trial of 211 UK secondary care patients with CFS. Primary outcomes were the Chalder fatigue questionnaire and the physical functioning subscale of the short-form- 36 survey. Postal questionnaires assessed the primary outcomes and cost-effectiveness of the intervention 12-months after randomisation. Service costs and quality-adjusted life years (QALYs) were combined in a cost-effectiveness analysis. Results: Between January 2014 and March 2016, 164 (78%) participants returned questionnaires 15- months after randomisation. Results showed no main effect of intervention arm on fatigue (chi2(1) = 4.8, p = 0.03) or physical functioning (chi2(1) = 1.3, p = 0.25), adjusting for multiplicity. No other intervention arm or time*arm effect was significant. The short-term fatigue reduction was maintained at long-term follow-up for participants assigned to GES, with improved fatigue from short- to long-term follow up after SMC, such that the groups no longer differed. Healthcare costs were £85 higher for GES and produced more QALYs. The incremental cost-effectiveness ratio was £4802 per QALY. Conclusions: The short-term improvements after GES were maintained at long-term follow-up, with further improvement in the SMC group such that the groups no longer differed at long-term follow-up. The cost per QALY for GES compared to SMC alone was below the usual threshold indicating cost-effectiveness, but with uncertainty around the result.

Item Type:	Article
Uncontrolled Keywords:	chronic fatigue syndrome,graded exercise therapy
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User:	LivePure Connector
Date Deposited:	15 Apr 2021 23:51
Last Modified:	06 Jun 2024 15:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/79794
DOI:	10.1016/j.jpsychores.2021.110484

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