A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector

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Witek, Kamil, Lin, Xiao, Karki, Hari S., Jupe, Florian, Witek, Agnieszka I., Steuernagel, Burkhard, Stam, Remco, Van Oosterhout, Cock, Fairhead, Sebastian, Heal, Robert, Cocker, Jonathan M., Bhanvadia, Shivani, Barrett, William, Wu, Chih-Hang, Adachi, Hiroaki, Song, Tianqiao, Kamoun, Sophien, Vleeshouwers, Vivianne G. A. A., Tomlinson, Laurence, Wulff, Brande B. H. and Jones, Jonathan D. G. (2021) A complex resistance locus in Solanum americanum recognizes a conserved Phytophthora effector. Nature Plants, 7 (2). pp. 198-208. ISSN 2055-026X

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Abstract

Late blight caused by Phytophthora infestans greatly constrains potato production. Many Resistance (R) genes were cloned from wild Solanum species and/or introduced into potato cultivars by breeding. However, individual R genes have been overcome by P. infestans evolution; durable resistance remains elusive. We positionally cloned a new R gene, Rpi-amr1, from Solanum americanum, that encodes an NRC helper-dependent CC-NLR protein. Rpi-amr1 confers resistance in potato to all 19 P. infestans isolates tested. Using association genomics and long-read RenSeq, we defined eight additional Rpi-amr1 alleles from different S. americanum and related species. Despite only ~90% identity between Rpi-amr1 proteins, all confer late blight resistance but differentially recognize Avramr1 orthologues and paralogues. We propose that Rpi-amr1 gene family diversity assists detection of diverse paralogues and alleles of the recognized effector, facilitating durable resistance against P. infestans.

Item Type:	Article
Faculty \ School:	Faculty of Science > The Sainsbury Laboratory Faculty of Science > School of Environmental Sciences Faculty of Science > School of Biological Sciences
UEA Research Groups:	Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation Faculty of Science > Research Groups > Plant Sciences
Related URLs:	http://www.scopus.com/inward/record.url?... http://www.nature.com/articles/s41477-02...
Depositing User:	LivePure Connector
Date Deposited:	19 Mar 2021 01:02
Last Modified:	06 Feb 2025 09:46
URI:	https://ueaeprints.uea.ac.uk/id/eprint/79507
DOI:	10.1038/s41477-021-00854-9

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