Tools
Tools
Wang, Qi and Bao, Yongping 
ORCID: https://orcid.org/0000-0002-6425-0370
(2021)
Nanodelivery of natural isothiocyanates as a cancer therapeutic.
Free Radical Biology & Medicine, 167.
pp. 125-140.
ISSN 0891-5849
Preview |
PDF (Accepted_Manuscript)
- Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives. Download (1MB) | Preview |
Abstract
Natural isothiocyanates (ITCs) are phytochemicals abundant in cruciferous vegetables with the general structure, R–N=C=S. They are bioactive organosulfur compounds derived from the hydrolysis of glucosinolates by myrosinase. A significant number of isothiocyanates have been isolated from different plant sources that include broccoli, Brussels sprouts, cabbage, cauliflower, kale, mustard, wasabi, and watercress. Several ITCs have been demonstrated to possess significant pharmacological properties including: antioxidant, anti-inflammatory, anti-cancer and antimicrobial activities. Due to their chemopreventive effects on many types of cancer, ITCs have been regarded as a promising anti-cancer therapeutic agent without major toxicity concerns. However, their clinical application has been hindered by several factors including their low aqueous solubility, low bioavailability, instability as well as their hormetic effect. Moreover, the typical dietary uptake of ITCs consumed for promotion of good health may be far from their bioactive (or cytotoxic) dose necessary for cancer prevention and/or treatment. Nanotechnology is one of best options to attain enhanced efficacy and minimize hormetic effect for ITCs. Nanoformulation of ITCs leads to enhance stability of ITCs in plasma and emphasize on their chemopreventive effects. This review provides a summary of the potential bioactivities of ITCs, their mechanisms of action for the prevention and treatment of cancer, as well as the recent research progress in their nanodelivery strategies to enhance solubility, bioavailability, and anti-cancer efficacy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | allyl isothiocyanate,apoptosis,benzyl isothiocyanate,cancer cells,cancer therapeutic,nanodelivery system,nanoparticle,natural isothiocyanates,phenethyl isothiocyanate,sulforaphane,biochemistry,physiology (medical),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1300/1303 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 17 Mar 2021 00:42 |
| Last Modified: | 13 Nov 2023 17:49 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/79479 |
| DOI: | 10.1016/j.freeradbiomed.2021.02.044 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |