Breathlessness predicts survival in patients with malignant pleural effusions: Meta-analysis of individual patient data from five randomized controlled trials

Mishra, Eleanor K. ORCID: https://orcid.org/0000-0002-5903-3005, Muruganandan, Sanjeevan, Clark, Allan ORCID: https://orcid.org/0000-0003-2965-8941, Bhatnagar, Rahul, Maskell, Nick, Lee, Y. C. Gary and Rahman, Najib M. (2021) Breathlessness predicts survival in patients with malignant pleural effusions: Meta-analysis of individual patient data from five randomized controlled trials. Chest, 160 (1). pp. 351-357. ISSN 0012-3692

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Abstract

Background: Patients with malignant pleural effusions (MPEs) experience breathlessness and poor survival. Breathlessness is associated with poor survival in other conditions. Research Question: Is breathlessness, measured using a visual analog scale for dyspnea (VASD), associated with survival in patients with MPE? Study Design and Methods: Individual patient data from five randomized controlled trials of 553 patients undergoing interventions for MPE were analyzed. VASD was recorded at baseline and daily after intervention. Patients were followed up until death or end of trial. Univariate and multivariable Cox regression were used to identify factors associated with survival. Results: Baseline VASD was significantly associated with worse survival, with a hazard ratio of 1.10 (95% CI, 1.06-1.15) for a 10-mm increase in VASD. On multivariable regression, it remained a significant predictor of survival. Mean 7-day VASD and mean total VASD were also predictors of survival (mean 7-day VASD: hazard ratio [HR], 1.26 [95% CI, 1.19-1.34]; total VASD: HR, 1.25 [95% CI, 1.15-1.37]). Other predictors of survival were serum C-reactive protein level and tumor type. Previous treatment with chemotherapy, performance status, pleural fluid lactate dehydrogenase, serum albumin, hemoglobin, serum neutrophil:lymphocyte ratio, and size of effusion were associated with survival on univariate but not multivariable analysis. Interpretation: Breathlessness, measured using VASD at baseline and postprocedure, is a predictor of survival in patients with MPE.

Item Type:	Article
Uncontrolled Keywords:	breathlessness,malignant pleural effusion,survival,pulmonary and respiratory medicine,critical care and intensive care medicine,cardiology and cardiovascular medicine ,/dk/atira/pure/subjectarea/asjc/2700/2740
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Respiratory and Airways Group Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health Faculty of Medicine and Health Sciences > Research Groups > Health Services and Primary Care Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Centres > Population Health
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	13 Mar 2021 00:47
Last Modified:	19 Oct 2023 02:55
URI:	https://ueaeprints.uea.ac.uk/id/eprint/79459
DOI:	10.1016/j.chest.2021.02.052

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