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Teng, Nancy, Price, Christopher, Mckee, Alastair, Hall, Lindsay 
ORCID: https://orcid.org/0000-0001-8938-5709 and Robinson, Stephen ORCID: https://orcid.org/0000-0002-6606-7588
(2021)
Exploring the impact of gut microbiota and diet on breast cancer risk and progression.
International Journal of Cancer, 149 (3).
pp. 494-504.
ISSN 0020-7136
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Abstract
There is emerging evidence that resident microbiota communities, that is, the microbiota, play a key role in cancer outcomes and anticancer responses. Although this has been relatively well studied in colorectal cancer and melanoma, other cancers, such as breast cancer (BrCa), have been largely overlooked to date. Importantly, many of the environmental factors associated with BrCa incidence and progression are also known to impact the microbiota, for example, diet and antibiotics. Here, we explore BrCa risk factors from large epidemiology studies and microbiota associations, and more recent studies that have directly profiled BrCa patients' gut microbiotas. We also discuss how in vivo studies have begun to unravel the immune mechanisms whereby the microbiota may influence BrCa responses, and finally we examine how diet and specific nutrients are also linked to BrCa outcomes. We also consider future research avenues and important considerations with respect to study design and implementation, and we highlight some of the important unresolved questions, which currently limit our overall understanding of the mechanisms underpinning microbiota‐BrCa responses.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antibiotics,breast cancer,diet,immune,microbiota,oncology,cancer research,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/2700/2730 |
| Faculty \ School: | Faculty of Science > School of Biological Sciences Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging Faculty of Science > Research Groups > Cells and Tissues |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 17 Feb 2021 13:05 |
| Last Modified: | 09 Apr 2024 02:57 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/79275 |
| DOI: | 10.1002/ijc.33496 |
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