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ToolsShibata, Marcelo C., Curl-Roper, Jordan, van Veldhuisen, Dirk J., Roughton, Michael, Coats, Andrew J. S. and Flather, Marcus (2021) Six-minute walk test: Prognostic value and effects of nebivolol versus placebo in elderly patients with heart failure from the SENIORS trial. Clinical Research in Cardiology, 110 (8). 1193–1201. ISSN 1861-0684
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Abstract
Background: There is limited information about the 6-min walk test (6MWT) in elderly patients with heart failure. We evaluated 6MWT and the effect of nebivolol on 6MWT from the SENIORS trial. Methods and results: The SENIORS trial evaluated nebivolol versus placebo on death and hospitalisation in patients aged ≥ 70 years with heart failure. A total of 1982 patients undertook a 6MWT at baseline and 1716 patients at 6 months. Patients were divided into tertiles (≤ 200 m, 201 to ≤ 300 m and > 300 m) and to change in distance walked between baseline and 6 months (< 0 m, 0 to < 30 m and ≥ 30 m). The primary outcome was all-cause mortality and cardiovascular hospital admission. Secondary endpoint was all-cause mortality. Baseline walk distance of ≤ 200 m incurred a greater risk of the primary and secondary outcomes (HR 1.41, CI 95% 1.17–1.69, p < 0.001) and (HR 1.37, CI 95% 1.05–1.78, p = 0.019). A decline in walk distance over 6 months was associated with increased risk of clinical events. Nebivolol had no influence on change in walk distance over 6 months. Conclusions: The 6MWT has prognostic utility in elderly patients. Those who walked less than 200 m were at highest risk. Nebivolol had no effect on 6MWT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | elderly,heart failure,prognosis,six-minute walk test,cardiology and cardiovascular medicine ,/dk/atira/pure/subjectarea/asjc/2700/2705 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 23 Jan 2021 00:55 |
| Last Modified: | 22 Oct 2022 07:39 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/78257 |
| DOI: | 10.1007/s00392-020-01768-w |
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