DNA G-quadruplex and i-motif structure formation is interdependent in human cells

King, Jessica J., Irving, Kelly L., Evans, Cameron W., Chikhale, Rupesh ORCID: https://orcid.org/0000-0001-5622-3981, Becker, Rouven, Morris, Chris ORCID: https://orcid.org/0000-0002-7703-4474, Peña Martinez, Cristian D., Schofield, Peter, Christ, Daniel, Hurley, Laurence H., Waller, Zoe, Iyer, K. Swaminathan and Smith, Nicole M. (2020) DNA G-quadruplex and i-motif structure formation is interdependent in human cells. Journal of the American Chemical Society, 142 (49). 20600–20604. ISSN 0002-7863

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Abstract

Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
UEA Research Groups: Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021)
Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter
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Depositing User: LivePure Connector
Date Deposited: 01 Dec 2020 00:55
Last Modified: 19 Jul 2023 00:55
URI: https://ueaeprints.uea.ac.uk/id/eprint/77847
DOI: 10.1021/jacs.0c11708

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