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King, Jessica J., Irving, Kelly L., Evans, Cameron W., Chikhale, Rupesh 
ORCID: https://orcid.org/0000-0001-5622-3981, Becker, Rouven, Morris, Chris ORCID: https://orcid.org/0000-0002-7703-4474, Peña Martinez, Cristian D., Schofield, Peter, Christ, Daniel, Hurley, Laurence H., Waller, Zoe, Iyer, K. Swaminathan and Smith, Nicole M.
(2020)
DNA G-quadruplex and i-motif structure formation is interdependent in human cells.
Journal of the American Chemical Society, 142 (49).
20600–20604.
ISSN 0002-7863
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Abstract
Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.
| Item Type: | Article |
|---|---|
| Faculty \ School: | Faculty of Science > School of Pharmacy (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Groups > Chemical Biology and Medicinal Chemistry (former - to 2021) Faculty of Science > Research Groups > Pharmaceutical Materials and Soft Matter |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 01 Dec 2020 00:55 |
| Last Modified: | 25 Sep 2024 15:10 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/77847 |
| DOI: | 10.1021/jacs.0c11708 |
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