A genomic catalog of Earth’s microbiomes

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Mock, Thomas ORCID: https://orcid.org/0000-0001-9604-0362 and IMG/M Data Consortium (2021) A genomic catalog of Earth’s microbiomes. Nature Biotechnology, 39 (4). 499–509. ISSN 1087-0156

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Abstract

The reconstruction of bacterial and archaeal genomes from shotgun metagenomes has enabled insights into the ecology and evolution of environmental and host-associated microbiomes. Here we applied this approach to >10,000 metagenomes collected from diverse habitats covering all of Earth’s continents and oceans, including metagenomes from human and animal hosts, engineered environments, and natural and agricultural soils, to capture extant microbial, metabolic and functional potential. This comprehensive catalog includes 52,515 metagenome-assembled genomes representing 12,556 novel candidate species-level operational taxonomic units spanning 135 phyla. The catalog expands the known phylogenetic diversity of bacteria and archaea by 44% and is broadly available for streamlined comparative analyses, interactive exploration, metabolic modeling and bulk download. We demonstrate the utility of this collection for understanding secondary-metabolite biosynthetic potential and for resolving thousands of new host linkages to uncultivated viruses. This resource underscores the value of genome-centric approaches for revealing genomic properties of uncultivated microorganisms that affect ecosystem processes.

Item Type:	Article
Additional Information:	Correction at: 10.1038/s41587-021-00898-4
Uncontrolled Keywords:	biotechnology,bioengineering,applied microbiology and biotechnology,molecular medicine,biomedical engineering ,/dk/atira/pure/subjectarea/asjc/1300/1305
Faculty \ School:	Faculty of Science > School of Environmental Sciences
UEA Research Groups:	Faculty of Science > Research Centres > Centre for Ecology, Evolution and Conservation Faculty of Science > Research Groups > Environmental Biology Faculty of Science > Research Groups > Centre for Ocean and Atmospheric Sciences
Related URLs:	http://www.scopus.com/inward/record.url?... http://www.nature.com/articles/s41587-02...
Depositing User:	LivePure Connector
Date Deposited:	21 Nov 2020 00:51
Last Modified:	13 Apr 2023 14:01
URI:	https://ueaeprints.uea.ac.uk/id/eprint/77751
DOI:	10.1038/s41587-020-0718-6

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