Long-distance endosome trafficking drives fungal effector production during plant infection

Bielska, Ewa, Higuchi, Yujiro, Schuster, Martin, Steinberg, Natascha, Kilaru, Sreedhar, Talbot, Nicholas J. ORCID: https://orcid.org/0000-0001-6434-7757 and Steinberg, Gero (2014) Long-distance endosome trafficking drives fungal effector production during plant infection. Nature Communications, 5 (1). ISSN 2041-1723

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To cause plant disease, pathogenic fungi can secrete effector proteins into plant cells to suppress plant immunity and facilitate fungal infection. Most fungal pathogens infect plants using very long strand-like cells, called hyphae, that secrete effectors from their tips into host tissue. How fungi undergo long-distance cell signalling to regulate effector production during infection is not known. Here we show that long-distance retrograde motility of early endosomes (EEs) is necessary to trigger transcription of effector-encoding genes during plant infection by the pathogenic fungus Ustilago maydis. We demonstrate that motor-dependent retrograde EE motility is necessary for regulation of effector production and secretion during host cell invasion. We further show that retrograde signalling involves the mitogen-activated kinase Crk1 that travels on EEs and participates in control of effector production. Fungal pathogens therefore undergo long-range signalling to orchestrate host invasion.

Item Type: Article
Faculty \ School: Faculty of Science > The Sainsbury Laboratory
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
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Depositing User: LivePure Connector
Date Deposited: 11 Nov 2020 01:16
Last Modified: 21 Apr 2023 00:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/77632
DOI: 10.1038/ncomms6097


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