Long-distance endosome trafficking drives fungal effector production during plant infection

Bielska, Ewa, Higuchi, Yujiro, Schuster, Martin, Steinberg, Natascha, Kilaru, Sreedhar, Talbot, Nicholas J. ORCID: https://orcid.org/0000-0001-6434-7757 and Steinberg, Gero (2014) Long-distance endosome trafficking drives fungal effector production during plant infection. Nature Communications, 5 (1). ISSN 2041-1723

Preview

PDF (Published_Version) - Published Version Available under License Creative Commons Attribution. Download (2MB) | Preview

Abstract

To cause plant disease, pathogenic fungi can secrete effector proteins into plant cells to suppress plant immunity and facilitate fungal infection. Most fungal pathogens infect plants using very long strand-like cells, called hyphae, that secrete effectors from their tips into host tissue. How fungi undergo long-distance cell signalling to regulate effector production during infection is not known. Here we show that long-distance retrograde motility of early endosomes (EEs) is necessary to trigger transcription of effector-encoding genes during plant infection by the pathogenic fungus Ustilago maydis. We demonstrate that motor-dependent retrograde EE motility is necessary for regulation of effector production and secretion during host cell invasion. We further show that retrograde signalling involves the mitogen-activated kinase Crk1 that travels on EEs and participates in control of effector production. Fungal pathogens therefore undergo long-range signalling to orchestrate host invasion.

Item Type:	Article
Faculty \ School:	Faculty of Science > The Sainsbury Laboratory
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging
Related URLs:	http://www.nature.com/articles/ncomms609...
Depositing User:	LivePure Connector
Date Deposited:	11 Nov 2020 01:16
Last Modified:	21 Apr 2023 00:51
URI:	https://ueaeprints.uea.ac.uk/id/eprint/77632
DOI:	10.1038/ncomms6097

Downloads

Actions (login required)

View Item