Tools
Tools
Osman, Deenah, Cooke, Anastasia, Young, Tessa R., Deery, Evelyne, Robinson, Nigel J. and Warren, Martin J. 
ORCID: https://orcid.org/0000-0002-6028-6456
(2021)
The requirement for cobalt in vitamin B12: A paradigm for protein metalation.
Biochimica Et Biophysica Acta-Molecular Cell Research, 1868 (1).
ISSN 0167-4889
Preview |
PDF (Accepted_Manuscript)
- Accepted Version
Available under License Creative Commons Attribution. Download (2MB) | Preview |
Preview |
PDF (Published_Version)
- Published Version
Available under License Creative Commons Attribution. Download (5MB) | Preview |
Abstract
Vitamin B12, cobalamin, is a cobalt-containing ring-contracted modified tetrapyrrole that represents one of the most complex small molecules made by nature. In prokaryotes it is utilised as a cofactor, coenzyme, light sensor and gene regulator yet has a restricted role in assisting only two enzymes within specific eukaryotes including mammals. This deployment disparity is reflected in another unique attribute of vitamin B12 in that its biosynthesis is limited to only certain prokaryotes, with synthesisers pivotal in establishing mutualistic microbial communities. The core component of cobalamin is the corrin macrocycle that acts as the main ligand for the cobalt. Within this review we investigate why cobalt is paired specifically with the corrin ring, how cobalt is inserted during the biosynthetic process, how cobalt is made available within the cell and explore the cellular control of cobalt and cobalamin levels. The partitioning of cobalt for cobalamin biosynthesis exemplifies how cells assist metalation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | chelation,cobalamin,cobamide,homeostasis,metals,sensors,molecular biology,cell biology ,/dk/atira/pure/subjectarea/asjc/1300/1312 |
| Faculty \ School: | Faculty of Science |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Centres > Norwich Institute for Healthy Aging |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 28 Oct 2020 01:14 |
| Last Modified: | 25 Sep 2024 15:07 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/77453 |
| DOI: | 10.1016/j.bbamcr.2020.118896 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |