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Haddad, Peter M., Pal, B. R., Clarke, P. 
ORCID: https://orcid.org/0000-0001-6203-7632, Wieck, A. and Sridhiran, S.
(2005)
Neonatal symptoms following maternal paroxetine treatment:Serotonin toxicity or paroxetine discontinuation syndrome?
Journal of Psychopharmacology, 19 (5).
pp. 554-557.
ISSN 0269-8811
Abstract
We report a case of neonatal symptoms of irritability, increased tonus and convulsions after in-utero exposure to paroxetine 30mg/day. The infant's symptoms commenced on the first day after birth and persisted for 10 days. Paroxetine levels were undetectable on day 6. Extensive investigations excluded infective and metabolic causes. Serotonin toxicity due to paroxetine seems the most likely mechanism, though an important differential diagnosis is a paroxetine discontinuation (withdrawal) syndrome. Differentiating between these two syndromes in the neonate presents a dilemma for clinicians. Irrespective of the mechanism, we recommend that all neonates exposed to antidepressants, particularly serotonin reuptake inhibitors (SSRIs), during the last trimester should be followed-up closely for adverse symptoms commencing in the first 10 days after birth. The possibility of such symptoms needs to be discussed with women who are considering starting or continuing antidepressant treatment in pregnancy. All neonatal adverse drug events should be reported to a pharmacovigilance centre. Further research is warranted.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | antidepressants,neonate,pregnancy,selective serotonin reuptake inhibitors,serotonin syndrome,withdrawal syndrome,pharmacology,psychiatry and mental health,pharmacology (medical),sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/3000/3004 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 19 Oct 2020 23:59 |
| Last Modified: | 22 Oct 2022 07:19 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/77354 |
| DOI: | 10.1177/0269881105056554 |
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