Antimicrobial susceptibility testing of invasive isolates of Streptococcus pneumoniae from Canadian patients:the SAVE study, 2011-15

Canadian Antimicrobial Resistance Alliance (CARA) (2018) Antimicrobial susceptibility testing of invasive isolates of Streptococcus pneumoniae from Canadian patients:the SAVE study, 2011-15. Journal of Antimicrobial Chemotherapy, 73 (suppl_7). vii5-vii11. ISSN 0305-7453

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Abstract

Objectives: To assess antimicrobial susceptibility for 14 agents tested against 6001 invasive isolates of Streptococcus pneumoniae cultured from invasive patient samples from 2011 to 2015 as a part of the annual SAVE study. Methods: Isolates of S. pneumoniae were tested using the standard CLSI broth microdilution method (M07-A10, 2015) with MICs interpreted by CLSI M100 27th Edition (2017) MIC breakpoints. Results: From 2011 to 2015, small but significant increases (P ≤ 0.05) in the percentage susceptibility for penicillin (interpreted by all three CLSI MIC breakpoint criteria) (increase of 1.7%-3.2%), clindamycin (3.1%) and ceftriaxone (interpreted by non-meningitis and meningitis CLSI MIC breakpoint criteria) (1.1%-1.5%) were observed. Susceptibility rates for clarithromycin and other commonly tested antimicrobial agents remained unchanged (P > 0.05) over the 5 year period. Isolates with an MDR phenotype (resistance to three or more antimicrobial agent classes) decreased significantly (P < 0.001) from 8.5% in 2011 to 5.6% in 2015. Antimicrobial susceptibility rates were not generally associated (P > 0.05) with patient gender (exception: clarithromycin) but were associated (P ≤ 0.05) with patient age (chloramphenicol and clindamycin) or specimen source (penicillin, doxycycline, trimethoprim/sulfamethoxazole and clindamycin), as well as geographic location in Canada and concurrent resistance to penicillin or clarithromycin. Conclusions: The in vitro susceptibility of invasive isolates of S. pneumoniae in Canada to penicillin, clindamycin and ceftriaxone increased from 2011 to 2015, coincident with a significant decrease in MDR phenotypes.

Item Type:	Article
Uncontrolled Keywords:	adolescent,adult,age factors,aged,pharmacology,canada,pharmacology,pharmacology,drug resistance, multiple, bacterial,female,humans,male,microbial sensitivity tests,middle aged,pharmacology,blood,microbiology,risk factors,drug effects,young adult
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	LivePure Connector
Date Deposited:	07 Oct 2020 23:58
Last Modified:	03 Nov 2022 16:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/77161
DOI:	10.1093/jac/dky156

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