Tools
Tools
Mushtaq, Shazad, Sadouki, Zahra, Vickers, Anna, Livermore, David 
ORCID: https://orcid.org/0000-0002-9856-3703 and Woodford, Neil
(2020)
In vitro activity of cefiderocol, a siderophore-cephalosporin, against multidrug-resistant gram-negative bacteria.
Antimicrobial Agents and Chemotherapy, 64 (12).
ISSN 0066-4804
Preview |
PDF (Published_Version)
- Published Version
Available under License Creative Commons Attribution. Download (359kB) | Preview |
Abstract
Cefiderocol is a parenteral siderophore cephalosporin, with a catechol-containing 3′ substituent. We evaluated its MICs against gram-negative bacteria, using iron-depleted Mueller-Hinton broth. The panel comprised 305 Enterobacterales, 111 P. aeruginosa and 99 A. baumannii, all selected for carbapenem resistance and multi-resistance to other agents. At 2 and 4 μg/ml cefiderocol inhibited 78.7% and 92.1% respectively of all Enterobacterales tested, with rates of 80-100% for isolates with all modes of carbapenem resistance except NDM enzymes (41.0% inhibited at 2 μg/ml, 72.1% at 4 μg/ml) or combinations of ESBL and porin-loss (61.5% inhibited at 2 μg/ml, 88.5% at 4 μg/ml). Cefiderocol also inhibited 81.1% and 86.5% of all P. aeruginosa at 2 and 4 μg/ml respectively, with rates of 80-100% for isolates with VIM, IMP, GES or VEB β-lactamases and slightly lower rates for those with NDM (45.5% at 2 μg/ml and 72.7% at 4 μg/ml) and PER (66.7% at 2 μg/ml and 73.3% at 4 μg/ml) enzymes; 63.3% of P. aeruginosa were inhibited at the FDA's 1 μg/ml breakpoint. Lastly, cefiderocol 2 and 4 μg/ml inhibited 80.8% and 88.9% of the A. baumannii isolates respectively, with rates >85% for isolates with OXA-51-like, -23, -24, or -58 enzymes and 50% at 2 μg/ml and 80% at 4 μg/ml for those with NDM carbapenemases. Dipicolinic acid and avibactam weakly potentiated cefiderocol against Enterobacterales with MBLs and serine carbapenemase respectively, indicating incomplete β-lactamase stability.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | acinetobacter baumannii,antimicrobial activity,antimicrobial resistance,carbapenamase,cefiderocol,enterobacterales,enterobacteriaceae,multidrug resistance,ndm,pseudomonas aeruginosa,pharmacology,pharmacology (medical),infectious diseases,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/3000/3004 |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023) Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 03 Sep 2020 23:57 |
| Last Modified: | 22 Oct 2022 06:53 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/76763 |
| DOI: | 10.1128/AAC.01582-20 |
Downloads
Downloads per month over past year
Actions (login required)
 |
View Item |