A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid

Dai, Letian, Zhang, Zhi, Winyard, Paul G., Gaffney, Karl ORCID: https://orcid.org/0000-0002-7863-9176, Jones, Hugh, Blake, David R. and Morris, Christopher J. (1997) A modified form of low-density lipoprotein with increased electronegative charge is present in rheumatoid arthritis synovial fluid. Free Radical Biology & Medicine, 22 (4). pp. 705-710. ISSN 0891-5849

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Abstract

Reactive oxygen species (ROS) are pro-inflammatory factors in the pathogenesis of rheumatoid arthritis. During inflammation, the amount of low-density lipoprotein (LDL) in the inflamed joint is increased. LDL is known to be susceptible to oxidation by ROS. Oxidized LDL may serve as a mediator for joint damage, further exacerbating the inflammatory process. LDL isolated from synovial fluid and plasma from individual patients (paired samples) with rheumatoid arthritis or osteoarthritis was characterized by crossed immunoelectrophoresis. On analysis by this technique, synovial fluid LDL from most patients with rheumatoid arthritis contained two peaks: one corresponding to normal plasma native LDL, and the other having an increased electrophoretic mobility associated with oxidized LDL. Paired plasma LDL samples contained native LDL alone, as did paired synovial fluid and plasma LDL from patients with osteoarthritis. Thus, in addition to native LDL, a second form of LDL was shown to be present in rheumatoid synovial fluid, which had properties consistent with those of oxidized LDL.

Item Type:	Article
Uncontrolled Keywords:	aged,blood,electrochemistry,female,humans,immunoelectrophoresis, two-dimensional,blood,male,middle aged,blood,oxidation-reduction,metabolism,metabolism
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	LivePure Connector
Date Deposited:	26 Aug 2020 00:02
Last Modified:	22 Oct 2022 06:40
URI:	https://ueaeprints.uea.ac.uk/id/eprint/76643
DOI:	10.1016/s0891-5849(96)00389-9

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