Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Barton, Anne, Thomson, Wendy, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Plant, Darren, Gibbons, Laura J., , Wellcome Trust Case Control Consortium, , YEAR Consortium, , BIRAC Consortium, Wilson, Anthony G., Bax, Deborah E., Morgan, Ann W., Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille and Worthington, Jane (2008) Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics, 40 (10). pp. 1156-1159. ISSN 1061-4036

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The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Item Type: Article
Uncontrolled Keywords: genetics,case-control studies,chromosome mapping,genetics,genetics,genetics,genetic linkage,genetics,humans,genetics
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: LivePure Connector
Date Deposited: 26 Aug 2020 00:01
Last Modified: 20 Oct 2020 23:56
URI: https://ueaeprints.uea.ac.uk/id/eprint/76618
DOI: 10.1038/ng.218

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