Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Barton, Anne, Thomson, Wendy, Ke, Xiayi, Eyre, Steve, Hinks, Anne, Bowes, John, Plant, Darren, Gibbons, Laura J., Wilson, Anthony G., Bax, Deborah E., Morgan, Ann W., Emery, Paul, Steer, Sophia, Hocking, Lynne, Reid, David M., Wordsworth, Paul, Harrison, Pille and Worthington, Jane and Wellcome Trust Case Control Consortium, YEAR Consortium, BIRAC Consortium (2008) Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nature Genetics, 40 (10). pp. 1156-1159. ISSN 1061-4036

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Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Item Type:	Article
Uncontrolled Keywords:	genetics,case-control studies,chromosome mapping,genetics,genetics,genetics,genetic linkage,genetics,humans,genetics,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User:	LivePure Connector
Date Deposited:	26 Aug 2020 00:01
Last Modified:	03 Nov 2022 16:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/76618
DOI:	10.1038/ng.218

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