Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum

Shiu, Winnie Ka Po and Gibbons, Simon (2009) Dibenzofuran and pyranone metabolites from Hypericum revolutum ssp. revolutum and Hypericum choisianum. Phytochemistry, 70 (3). pp. 403-406. ISSN 0031-9422

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Abstract

In a project to isolate and characterise anti-staphylococcal compounds from members of the genus Hypericum, a dibenzofuran and a pyranone were isolated from the dichloromethane and hexane extracts of Hypericum revolutum ssp. revolutum Vahl (Guttiferae) and Hypericum choisianum Wall. ex. N. Robson (Guttiferae), respectively. The structures of these compounds were elucidated by 1- and 2D-NMR spectroscopy and mass spectrometry as 3-hydroxy-1,4,7-trimethoxydibenzofuran (1) and 4-(3-O-3″)-3″-methylbutenyl-6-phenyl-pyran-2-one (2). The metabolites were evaluated against a panel of multidrug-resistant strains of Staphylococcus aureus. Compound 1 exhibited a minimum inhibitory concentration (MIC) of 256 μg/ml, whereas compound 2 was inactive at a concentration of 512 μg/ml.

Item Type:	Article
Uncontrolled Keywords:	antibacterial,dibenzofuran,guttiferae,hypericum choisianum,hypericum revolutum,mdr,mrsa,pyran-2-one,pyranone,staphylococcus aureus,biochemistry,molecular biology,plant science,horticulture ,/dk/atira/pure/subjectarea/asjc/1300/1303
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://www.scopus.com/inward/record.url?...
Depositing User:	LivePure Connector
Date Deposited:	15 Jul 2020 23:39
Last Modified:	22 Oct 2022 06:29
URI:	https://ueaeprints.uea.ac.uk/id/eprint/76127
DOI:	10.1016/j.phytochem.2008.12.016

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