Rapid detection of sildenafil analogue in Eurycoma longifolia products using a new two-tier procedure of the near infrared (NIR) spectra database

Said, Mazlina Mohd, Gibbons, Simon, Moffat, Anthony C. and Zloh, Mire (2014) Rapid detection of sildenafil analogue in Eurycoma longifolia products using a new two-tier procedure of the near infrared (NIR) spectra database. Food Chemistry, 158. pp. 296-301. ISSN 0308-8146

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Abstract

A simple and cost-effective two-tier drug screening procedure comprises a 'dedicated' NIR spectral database of common medicines and a 'unified' database was developed to detect the sildenafil analogue in Eurycoma longifolia products. Diffuse reflectance spectra of ten commercial herbal products containing E. longifolia were obtained over the wavelength range of 1100-2500 nm. The spectral search of two products purchased via the internet against a dedicated database of reputable E. longifolia products have resulted in the similarity index of more than 0.1 which indicated significantly different spectra. Further searches against the unified database showed a close match to the spectra of drug containing sildenafil citrate suggesting the presence of a sildenafil analogue. This finding was supported by clustering of these spectra in the PCA score plot within 5 2014 Elsevier Ltd. All rights reserved.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Depositing User:	LivePure Connector
Date Deposited:	14 Jul 2020 23:51
Last Modified:	22 Oct 2022 06:28
URI:	https://ueaeprints.uea.ac.uk/id/eprint/76061
DOI:	10.1016/j.foodchem.2014.02.125

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