The genus Hypericum—a valuable resource of anti-Staphylococcal leads

Gibbons, Simon, Ohlendorf, Birgit and Johnsen, Inga (2002) The genus Hypericum—a valuable resource of anti-Staphylococcal leads. Fitoterapia, 73 (4). pp. 300-304. ISSN 0367-326X

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Abstract

In the present study, extracts of 34 species and varieties of the genus Hypericum were screened for activity against a clinical isolate of methicillin-resistant Staphylococcus aureus, which in addition possessed a multidrug efflux mechanism conferring a high level of resistance to therapeutically useful antibiotics. Thirty-three of the 34 chloroform extracts showed significant activity in a disk diffusion assay, and five extracts had minimum inhibitory concentrations of 64 μg/ml, indicating that this genus has great potential to yield compounds with potent activity against multidrug-resistant bacteria.

Item Type: Article
Faculty \ School: Faculty of Science > School of Pharmacy
Related URLs:
Depositing User: LivePure Connector
Date Deposited: 10 Jul 2020 00:07
Last Modified: 10 Jul 2020 00:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/75998
DOI: 10.1016/S0367-326X(02)00082-5

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