The genus Hypericum—a valuable resource of anti-Staphylococcal leads

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Gibbons, Simon, Ohlendorf, Birgit and Johnsen, Inga (2002) The genus Hypericum—a valuable resource of anti-Staphylococcal leads. Fitoterapia, 73 (4). pp. 300-304. ISSN 0367-326X

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Abstract

In the present study, extracts of 34 species and varieties of the genus Hypericum were screened for activity against a clinical isolate of methicillin-resistant Staphylococcus aureus, which in addition possessed a multidrug efflux mechanism conferring a high level of resistance to therapeutically useful antibiotics. Thirty-three of the 34 chloroform extracts showed significant activity in a disk diffusion assay, and five extracts had minimum inhibitory concentrations of 64 μg/ml, indicating that this genus has great potential to yield compounds with potent activity against multidrug-resistant bacteria.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	https://linkinghub.elsevier.com/retrieve...
Depositing User:	LivePure Connector
Date Deposited:	10 Jul 2020 00:07
Last Modified:	22 Oct 2022 06:27
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75998
DOI:	10.1016/S0367-326X(02)00082-5

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