Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta

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Gibbons, Simon, Fallah, Fatemeh and Wright, Colin W. (2003) Cryptolepine hydrochloride: a potent antimycobacterial alkaloid derived from Cryptolepis sanguinolenta. Phytotherapy Research, 17 (4). pp. 434-436. ISSN 0951-418X

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Abstract

The activity of cryptolepine hydrochloride, a salt of the main indoloquinoline alkaloid from the West African medicinal plant Cryptolepis sanguinolenta , was assessed against the fast growing mycobacterial species Mycobacterium fortuitum , which has recently been shown to be of use in the evaluation of antitubercular drugs. The low minimum inhibitory concentration (MIC) of this compound (16 µg/mL) prompted further evaluation against other fast growing mycobacteria namely, M. phlei , M. aurum , M. smegmatis , M. bovis BCG and M. abcessus and the MICs ranged over 2–32 µg/mL for these species. The strong activity of this agent, the need for new antibiotics with activity against Mycobacterium tuberculosis , coupled with the ethnobotanical use of C. sanguinolenta extracts to treat infections, highlight the potential of the cryptolepine template for development of antimycobacterial agents.

Item Type:	Article
Uncontrolled Keywords:	sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School:	Faculty of Science > School of Pharmacy
Related URLs:	http://doi.wiley.com/10.1002/ptr.1284
Depositing User:	LivePure Connector
Date Deposited:	10 Jul 2020 00:07
Last Modified:	22 Oct 2022 06:27
URI:	https://ueaeprints.uea.ac.uk/id/eprint/75994
DOI:	10.1002/ptr.1284

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