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Kergreis, Angelique, Lord, Rianne M. 
ORCID: https://orcid.org/0000-0001-9981-129X and Pike, Sarah J.
(2020)
Influence of ligand and nuclearity on the cytotoxicity of cyclometallated C^N^C platinum(II) complexes.
Chemistry - A European Journal, 26 (65).
pp. 14938-14946.
ISSN 0947-6539
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Abstract
A series of cyclometallated mono- and di-nuclear platinum(II) complexes and the parent organic ligand, 2,6-diphenylpyridine 1 (HC^N^CH), have been synthesized and characterized. This library of compounds includes [(C^N^C)Pt(II)(L)] (L = dimethylsulfoxide (DMSO) 2 and triphenylphosphine (PPh3) 3) and [((C^N^C)Pt(II))2(L`)] (where L` = N-heterocycles (pyrazine (pyr) 4, 4,4,`-bipyridine (4,4`-bipy) 5 or diphosphine (1,4-bis(diphenylphosphino)butane (dppb) 6). Their cytotoxicity was assessed against four cancerous cell lines and one normal cell line, with results highlighting significantly increased antiproliferative activity for the dinuclear complexes (4-6), when compared to the mononucleated species (2 and 3). Complex 6 is the most promising candidate, displaying very high selectivity towards cancerous cells, with selectivity index (SI) values > 29.5 (A2780) and > 11.2 (A2780cisR), and outperforming cisplatin by > 4-fold and > 18-fold respectively.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | anticancer,bioinorganic chemistry,cyclometallated platinum(ii),multinuclear complexes,phosphine ligands,catalysis,organic chemistry,sdg 3 - good health and well-being ,/dk/atira/pure/subjectarea/asjc/1500/1503 |
| Faculty \ School: | Faculty of Science > School of Chemistry (former - to 2024) |
| UEA Research Groups: | Faculty of Science > Research Centres > Centre for Molecular and Structural Biochemistry Faculty of Science > Research Groups > Chemistry of Life Processes Faculty of Science > Research Groups > Chemistry of Materials and Catalysis |
| Related URLs: | |
| Depositing User: | LivePure Connector |
| Date Deposited: | 02 Jul 2020 00:04 |
| Last Modified: | 21 Oct 2024 23:52 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/75877 |
| DOI: | 10.1002/chem.202002517 |
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